NMN, NR, niacinamide, nicotinamide, niacin, NAD+ are all terms that one quickly comes across when dealing with the topic of healthy aging and longevity. Online you can find stores selling NMN as a chemical, advertised with a high degree of purity and Chinese certificate as well as the promise of a 30% longer life. But is there any truth in the hype? We want to create transparency regarding NAD+ and show which effects have already been robustly researched and which further potentials have been shown in isolated studies but not yet proven. We'll also go into how you can safely take NAD+ boosters.
What is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is one of the most important and fascinating molecules in our bodies. NAD+ is the fuel of mitochondria, the powerhouses of our cells. It is essential in the conversion of food into energy and plays a critical role in maintaining the DNA integrity. It also plays a key role in regulating almost all important biological processes. Most importantly, NAD+ can help us live healthier and longer life.
Agents such as NMN, NR and niacinamide are precursors of NAD+ that are converted into NAD+ by the body. The best known NAD+ booster is NMN, but it is not approved by the EU for human consumption. Therefore, consumers should always make sure that all ingredients of a food supplement have actually been classified as safe by the EFSA (European Food Safety Authority).
What effect has NAD+ been shown to have?
Studies show that without adequate NAD+ levels, our cells are unable to produce energy. As we age, NAD+ levels in the body decline (at age 50, levels are still about 50%, and at age 80, levels are only about 1-10% compared to young adults).
Supplementation with a NAD+ precursor such as nicotinamide, which is converted to NAD+ by the body, can help maintain NAD+ levels in the body and slow down the aging process of the cell (Study, Study).
What other potential of NAD+ boosters is being researched right now?
8 possible benefits of NAD+ Boosters
1. life expectancy
3. Memory performance
4. Cardiovascular system
7. Stem cells
8. DNA integrity
1. life expectancy
In studies with mammals, NAD+ boosters have been associated with increased life expectancy. For example, in mice there was a 5% increased life expectancy that took NAD+ boosters only in the last eighth of their lives.
People often report having more energy when they take NMN. Studies show that an orally administered NAD+ booster increased endurance and stamina in old mice by up to 80% increase.
3. memory performance
Studies in mice show that NAD+ boosters have a have a positive effect on brain function by, for example, improving cognition and blood flow in the brain.
The recognition of objects is again similar in older mice taking an NAD+ booster (NMN) (yellow bar) compared to young mice (gray bar). The orange bar represents aged mice without NAD+ booster.
4. cardiovascular system
Studies in mice show that NAD+ booster regenerate aged blood vessels and improve their elasticity.
Metabolism decreases significantly with age, leading to an increased risk of numerous diseases. Studies in mice show that NAD+ boosters reduce insulin resistance and reduce age-related weight gain weight gain.
Studies show that NAD+ boosters may increase Fertility of female mice (improved ovulation (improved ovulation rate, more live births, fewer miscarriages).
7. stem cells
As we age, the number of stem cells decreases and the remaining stem cells often become dysfunctional. This contributes to aging because stem cells generate new cells to maintain our tissues. Several studies show that increasing NAD levels can improve the health and self-renewal of stem cells. of stem cells.
8. DNA Integrity
Studies in mice show that NAD+ boosters contribute to the repair damaged DNA. DNA. DNA damage is one of the reasons we age.
What else is the NAD+ booster niacinamide useful for?
Niacinamide is also often sold as an external skin care product, such as a serum or cream. Applying niacinamide to the skin can help with wrinkles, aging, itching, mild acne and rosacea.
However, oral supplementation works even better for beautiful and healthy skin. Studies show that niacinamide has an anti-inflammatory effect and reduces reduces transepidermal water loss. Thus, redness is reduced and skin elasticity is improved. By being able to protect against skin damage caused by sun exposure, niacinamide helps to reduce fine lines and wrinkles. Studies also show that niacinamide can protect against certain types of skin cancer. skin cancers.